Nature Communications· Jie-Yan Zheng·· 17 小时前AI 评分58
pPVT-NAcMed 环路介导抗瘙痒反应,并区分组胺依赖与非依赖瘙痒
The posterior paraventricular nucleus of the thalamus to nucleus accumbens medial shell circuit mediates an anti-pruritic response
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研究显示,丘脑后室旁核到伏隔核内侧壳的 pPVT-NAcMed 环路对组胺依赖性与非依赖性瘙痒作出相反响应,外侧缰核(LH)输入对前者起缓冲作用。慢性瘙痒会降低该环路的突触后效能,促进敏化,并揭示两类瘙痒的差异化处理机制。
来源:Nature Communications · nature.com